HYPOTHESISunder reviewmechanismKDM6A

MN25_ROCK2 × KDM6A affinity via computational screening (Boltz-2)

Description

Boltz-2 iPTM ~0.9 for MN25_ROCK2 against KDM6A. Aggregates all screening calls in this iPTM band. Status=under_review until Chai-1 orthogonal validation (gated by hypothesis_action_generator).

Rationale

Boltz-2 structural prediction promoted to hypothesis for Chai-1 orthogonal validation + retrosynth + selectivity gating.

Related claims (16)

Type	Predicate	Conf	Source
protein interaction	boltz2_ppi_iptm	90%	dell_ppi:20260503:KDM6A_CAT__TP53_CTD_result
protein interaction	boltz2_ppi_iptm	90%	dell_ppi:20260429:KDM6A_CAT__SMN1_YGBOX_result
protein interaction	boltz2_ppi_iptm	89%	dell_ppi:20260504:TP53_CTD__KDM6A_CAT_result
protein interaction	boltz2_ppi_iptm	86%	dell_ppi:20260503:KDM6A_CAT__SMN1_TUDOR_result
protein interaction	boltz2_ppi_iptm	84%	dell_ppi:20260505:KDM6A_CAT__NRG1_EGF_result
protein interaction	boltz2_ppi_iptm	84%	dell_ppi:20260506:KDM6A_CAT__MDM2_NTD_result
protein interaction	boltz2_ppi_iptm	76%	dell_ppi:20260506:KDM6A_CAT__PAK1_PBD_result
protein interaction	boltz2_ppi_iptm	75%	dell_ppi:20260428:TP53_TAD__KDM6A_CAT_result
protein interaction	boltz2_ppi_iptm	73%	dell_ppi:20260505:KDM6A_CAT__TP53_TAD_result
protein interaction	boltz2_ppi_iptm	73%	dell_ppi:20260502:KDM6A_CAT__IGF1R_ECD_result
protein interaction	boltz2_ppi_iptm	73%	dell_ppi:20260427:TP53_OD__KDM6A_CAT_result
protein interaction	boltz2_ppi_iptm	72%	dell_ppi:20260502:KDM6A_CAT__TP53_OD_result
protein interaction	af3_iptm	29%	af3_archive_kdm6a_full_x_tet2_cat
protein interaction	af3_iptm	10%	af3_archive_kdm6a_cat_x_idh1_cat
other	af3_iptm	10%	af3_archive_kdm6a_cat_x_idh1_cat
other	af3_iptm	9%	af3_03_KDM6A_CHRNA1ecd_Boltz076_2026-04-22_2056