IDH1 Research Platform

Target Prioritization

COMPUTATIONAL

46 targets

Multi-criteria scoring across 7 dimensions: evidence strength, biological coherence, fragility relevance, interventionability, translational feasibility, novelty, and contradiction risk. Composite score determines Phase 3 priority.

▶How does Target Scoring work?

Each target receives a composite score from 8 independent dimensions, normalized 0–1 and combined via weighted average. Weights are transparent and reproducible (see the convergence engine).

Top 5 composite scores are Tier A (primary candidates), ranks 6–15 are Tier B (established modifiers), the remainder are Tier C (discovery).

Targets Scored

Tier A

Tier B

Tier C

60.5%

Top Score

46 / 46

#	Symbol	Composite	Volume	Quality	Coherence	Independence	Intervention	Translation	Network	Novelty
1	FGFR2	0.605	27	90	75	16	60	100	67	29
2	IDH1	0.587	100	86	75	53	46	100	20	0
3	BRAF	0.559	1	81	33	2	69	100	67	64
4	TP53	0.521	10	83	50	6	1	100	100	61
5	ERBB2	0.503	1	80	42	3	30	100	60	63
6	KRAS	0.502	13	83	50	3	6	100	73	60
7	IDH2	0.499	5	91	67	5	11	100	13	65
8	ARID1A	0.415	1	82	25	1	31	50	40	64
9	BRCA1	0.405	1	87	25	1	0	50	67	66
10	BAP1	0.383	1	69	33	1	4	100	13	60
11	PIK3CA	0.375	0	77	25	1	0	50	60	63
12	IDH2	0.305	0	81	8	0	0	50	0	64
13	IDH1	0.294	0	76	8	0	0	50	0	63
14	TP53_363_393	0.275	0	89	8	3	0	0	0	67
15	KDM6A_1080_1401	0.275	0	81	8	20	0	0	0	64
16	IDH1_None_None	0.271	0	88	8	1	0	0	0	66
17	TET2_1135_1180	0.269	0	83	8	9	0	0	0	65
18	DNMT3B_604_853	0.255	0	79	8	5	0	0	0	64
19	TP53_1_62	0.244	0	75	8	3	0	0	0	62
20	TP53_323_356	0.239	0	73	8	3	0	0	0	62
21	IDH2_R140Q	0.235	0	72	8	0	0	0	0	62
22	TET2_catalytic	0.196	0	54	8	2	0	0	0	56
23	KDM6A	0.190	1	50	8	6	0	0	0	55
24	IDH1_R132H	0.186	0	50	8	2	0	0	0	55
25	HIF1A	0.171	0	44	8	1	0	0	0	53
26	CDKN2A	0.170	0	0	0	0	0	50	67	40
27	IDH1_WT	0.170	0	43	8	1	0	0	0	53
28	BRCA2	0.146	0	0	0	0	0	50	40	40
29	NRAS	0.120	0	0	0	0	0	0	67	40
30	VHL	0.110	0	0	0	0	0	50	0	40
31	FH	0.096	0	10	8	1	0	0	0	43
32	PBRM1	0.090	0	0	0	0	0	0	33	40
33	MDM2_17_125	0.060	0	0	0	0	0	0	0	40
34	NRG1_176_246	0.060	0	0	0	0	0	0	0	40
35	PAK1_74_149	0.060	0	0	0	0	0	0	0	40
36	SMN1_260_294	0.060	0	0	0	0	0	0	0	40
37	SMN1_90_159	0.060	0	0	0	0	0	0	0	40
38	SRSF1_16_90	0.060	0	0	0	0	0	0	0	40
39	TET2	0.060	0	0	0	0	0	0	0	40
40	ATF3_None_None	0.060	0	0	0	0	0	0	0	40
41	BCL2_None_None	0.060	0	0	0	0	0	0	0	40
42	FUS_1_165	0.060	0	0	0	0	0	0	0	40
43	FUS_471_526	0.060	0	0	0	0	0	0	0	40
44	HNRNPA1_106_184	0.060	0	0	0	0	0	0	0	40
45	HSPA1A_1_400	0.060	0	0	0	0	0	0	0	40
46	IGF1R_31_468	0.060	0	0	0	0	0	0	0	40